Peptide Libraries/Peptide Synthesis//Peptide/Custom Peptide CAS NO.74381-53-6

We offer Peptide Libraries by Mimotopes. 

Peptide libraries are a powerful tool in biological research for screening large numbers of peptides in the search for the few, critical bioactive peptides. 

We offer Peptide Libraries by Mimotopes. 

Peptide libraries are a powerful tool in biological research for screening large numbers of peptides in the search for the few, critical bioactive peptides. 

 

Specialists of peptide library by Mimotopes could design peptide library for free based on customer requirements and experimental purposes,provide consultation and guidance of peptide library design and other customized services in connection with customer's practical problems.

 

Mimotopes library (PepsetTM) is synthesized on the original patent of mimotopes (SynPhase lantern),it makes the homogeneity and the stability of product's quality guaranteed. But also ensure the high efficiency of the production, and ensure that customers could receive the products in the shortest time.

 

The design tools below will guide you through the steps of isolating minimum length active peptide sequences, identifying critical amino acid residues, designing analogs for sequence optimization and will provide indicative pricing for all peptide sets.

 

Overlapping

Overlapping peptide libraries are ideal for T-cell epitope searching, because T cell epitopes are by nature short linear peptides from the primary protein sequence. They are also appropriate for scanning the primary sequence of proteins for linear, or "continuous", B-cell (antibody-defined) epitopes.

 

Truncation

Truncation peptide libraries are used to identify the shortest amino acid sequence needed for activity. The library is constructed by systemically removing the flanking residues of the original peptide. If the essential amino acids are known (eg. by Alanine Scanning), the direction of truncation can be tailored to maintain these residues, whilst truncating the opposite end.

 

T-cell Truncated

Truncated peptide libraries allow the testing of all possible T-cell epitopes (ie. all 8 to 11-mers) across a protein of interest. In each tube, we provide equimolar mixtures of the four C-terminal peptides for each nominal 11-mer. After screening, positive tubes can be deconvoluted for precise epitope identification.

 

Alanine Scan

Alanine Scanning is able to identify specific amino acid residues responsible for a peptide's activity. Alanine is used to substitute each residue sequentially.

Substitution of an essential amino acid results in a reduction in peptide activity, with the degree of activity reduction taken as a relative measure of the importance of the amino acid being substituted.

 

Positional Scan

Positional scanning is an important tool for peptide sequence optimization. This identifies an amino acid of interest at a single position and substitutes it with all other natural amino acids one at a time. Increases in activity will identify the preferred amino acid residues at this positions.

 

Combinatorial 2-Positional Scan

Positional scanning is an important tool for peptide sequence optimization. Two position combinatorial scanning identifies amino acids of interest at two given positions and substitutes them with all other natural amino acids one at a time. Increases in activity will identify the preferred amino acid residues at these positions.

 

Combinatorial 3-Positional Scan

Positional scanning is an important tool for peptide sequence optimization. Three position combinatorial scanning identifies amino acids of interest at three given positions and substitutes them with all other natural amino acids one at a time. Increases in activity will identify the preferred amino acid residues at these positions.

 

Scrambled

Scrambled libraries are constructed through permutation of the original peptide sequence. They are typically used as:

1. Negative controls to show that a specific sequence rather than the amino acid composition is critical for activity; or

2. A tool for finding new leads by creating a random screening library.